The 36-year-old carded a final-round 61 to finish second, three shots behind defending champion Tyrrell Hatton after threatening to score a magical 59. Likely dejected with missing out on that bit of history, Fisher then became guilty of letting his guard down as he missed the short birdie try, too, to walk off with just a par for his 11-under 61.
Hatton, who turns 26 next Saturday, did not drop a shot over his last 54 holes, a blistering run that gave him a second career Tour title and will lift him to 22nd in the world rankings.
Tyrrell Hatton grabbed one bit of history while Ross Fisher lost the chase of his fellow Englishman but snatched an equally significant historical milestone in the final blows of the Alfred Dunhill Links Championship.
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It leaves the leading pair eight shots clear of Fox, whose third round is at the Kingsbarns Golf Links.
'It's an unbelievable feeling, ' he said.
"I played baseball for two years, and even went to Japan". It felt like it was a lot harder today than it was previous year.
"This is thanks in great part to changes in the golf ball and the distance it travels". I just saw the lines and was hitting good putts and they were going in and I didn't want it to end.More news: Gordon Strachan blames genetics after missing out on World Cup play-offs
"I'm pretty chuffed because after 28 holes this week after Carnoustie on day one and then 10 holes at Kingsbarns, I was four-over-par for the tournament".
Fisher said: "I felt like there was a good one in me today because there wasn't much breeze". A par on the 16th hole, followed by a nifty up-and-down par save on the 17th (see below) left Fisher needing to eagle the drivable par-4 18th to break 60.
Frenchman Victor Dubuisson fired an impressive 63 but was still a massive seven shots off Hatton, while Marc Warren and Robert Rock shared fourth spot on 14 under alongside Gregory Bourdy.
"When you get St. Andrews on a day like this, it's definitely scoreable, but you still have to hit the shots", he said.More news: Saudi king in historic first visit to Russian Federation for talks with Putin
Donaldson, who pocketed a cheque for 50,000 USA dollars, had nine birdies and an 18th hole eagle on his card for a 72 hole score of 40-under-par, winning by three from Robert Rock and Westlife singer Brian McFadden, Victor Dubuisson and Shantanu Narayen, who had a hole-in-one in round three, and Yikeun Chang and Erwee Botha.