Cameron Artis-Payne ran for a one-yard touchdown early in the quarter.
Derrick Henry rushed in a 17-yard TD before the quarter ended.
That was the end of the day for Mariota, but not for the Titans. Cam Newton will play a major role in the team's attempt to get back on track but he continues to remain sidelined during the preseason.
Newton passed for 3,509 yards with 19 touchdowns and 14 interceptions in 15 games last season for the Panthers, who missed the playoffs after finishing last in the NFC South with a 6-10 record.More news: US Rep Gwen Moore calls to remove President Donald Trump from office
"It was a lot better", Mariota said. The defense got a huge, huge turnover.
The Titans opted to sit running back DeMarco Murray, which allowed Henry a chance to start again, and make plays. Cornerback Logan Ryan forced a fumble that Kevin Byard recovered, and Jaylon Brown's tipped pass was intercepted by Justin Staples.
On back-to-back drives, Henry and McCaffrey got points on the board with a 17-yard touchdown for each running back.
"It's a great sign", Mularkey said.More news: 3 children found dead inside home in Clinton
Titans coach Mike Mularkey challenged the offense after its lackluster preseason opener against the New York Jets. That's our intent. When you've got a lot of guys around the ball where they're supposed to be, good things happen, and that's exactly what happened.
The Carolina Panthers would make things interesting in the third quarter. That appears unlikely considering that the three-time Pro Bowler did participated in a Carolina's drill during the two joint practice sessions, and the first time the 28-year-old star quarterback threw passes defended by Tennessee Titans was on Thursday.
In Saturday's game, the Titans created turnovers on each of the Panthers' first two drives. The defense forced yet another fumble and David Fluellen, who led the Titans with 76 rushing yards, came in to finish it off capitalizing off the turnover with the game winning touchdown run.More news: Mattis: Any missile threatening Guam would be shot down