Lavrov last visited Washington in 2013.
The two men will meet in the Oval Office at 10:30 am (1430 GMT), according to the White House.
The Russian Foreign Ministry's statement says, "At the talks, [the top diplomats] will exchange views on topical world issues and pressing issues of bilateral relations".More news: Haniyeh Elected Meshaal's Successor while Authority Siege Hamas Through Taxes
Trump's talks with Russian Foreign Minister Sergey Lavrov would occur after the Russian's meetings earlier in the day with Secretary of State Rex Tillerson.
The talks came a day after Trump fired the FBI director who was overseeing an investigation into Russia's alleged interference in the 2016 presidential election.
On Tuesday, media reported that Lavrov would meet Trump during the working visit to the United States.More news: Delhi Metro hikes fare; minimum at Rs 10, maximum Rs 50
Relations soured further in April after the USA blamed Syria's president Bashar Assad, a key Russian ally, for a deadly chemical weapons attack on civilians and Mr Trump fired some 60 cruise missiles at a Syrian air base in response. Trump insisted that wasn't the case.
On Syria, where Russian Federation has backed President Bashar Assad's forces and the US has supported anti-Assad rebels, the talks appeared to indicate a slight narrowing of differences.
Russia, Turkey and Iran last week agreed on a plan for four "de-escalation zones" in the Arab country to quell a civil war that has killed some 400,000 people and contributed to global refugee and terror crises since erupting in 2011.More news: Le Pen's father says her stance on euro, Europe undermined her
The official, speaking on condition of anonymity, said on the agenda would be Syria as well as U.S. According to the Russian Foreign Ministry, Tillerson and Lavrov will exchange views on key problems of the worldwide agenda and discuss topical issues of the bilateral relations at the upcoming talks. The zones would not cover areas where the US -led coalition is fighting the Islamic State group, but enforcement and other questions remain unanswered. The White House declined a request for confirmation.